301: “Where’d she get the red hair?”

A sweet moment for a new family.  Claire and Frank are finally connecting, joyful over the birth of Brianna.

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“Where’d she get the red hair?”

Buzzkill.

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The nurse has no malicious intent.  Instead, she likely understands the Mendelian inheritance of red hair.  A child born with red hair carries two copies of the recessive gene for red hair – one from the mother and one from the father.  She of course then assumes that Claire or Frank likely has a redheaded family member they can recall in their line.

Of course, there is much more to the inheritance of hair color, including details of blonde, various browns, and black hair, but for today, lets focus on red.

We now know that the specific gene responsible for red hair is called melanocortin 1 receptor (or MC1R).  Red hair is a recessive trait.  Recalling back to genetics class, this means that for a person to be born with red hair, they must inherit a red hair gene from their mother and one from their father.  If only one red hair gene is inherited, the child will have brown hair and simply be a carrier of the red hair gene.

Could Frank and Claire have a biological child with red hair?  YES!

Setting aside the question of whether Frank Randall is indeed fertile to begin with (we will have to revisit that too!), here is an example showing how Claire and Frank might have a biological child with red hair. R indicates the dominant gene for brown hair and r indicates the recessive gene for red hair.  If each of them is a brown haired person who carries the red hair gene, they will have a 25% chance of their child being a redhead:

Claire and Frank

Indeed, Frank and Claire could have a redheaded biological child, though it would have been much more likely for Jamie and Claire.  Assuming that Claire carries the gene for red hair (and we know she does since we’ve seen Brianna!), each child of Jamie and Claire will have a 50% chance of having red hair.

Claire and Jamie

Frank and Claire had better get used to answering the question of the red hair.  No doubt this is only the first of hundreds of times they will be asked.

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While on the topic of red heads, here are some fun facts:

  • Only 1-2% of the human population has red hair.
  • About 13% of the population of Scotland has red hair, the highest concentration in the world.
  • Redheads are more sensitive to pain!  They require significantly more anesthetic to block pain.  This is thought to be due to the fact that the MC1R gene responsible for red hair also codes for a receptor that is related to a family of receptors involved in pain perception.
  • They are also more sensitive to cold tempeteratures
  • Redheads have a higher risk of skin cancer, specifically melanoma.
  • Redheads are more likely to be left handed than people with other hair colors!
  • Redheads tend not to go grey.  Their hair pigment lightens to blonde and white and avoids grey.
  • People with red hair actually have fewer strands of hair than those with other colors.   However, their red hair is thicker so it appears just as full.

 

So glad to be back in the world of Outlander!  Life has been pretty crazy and this is always a welcome diversion!  What did you think of the Season Three premiere?  I’ve been avoiding previews and teasers so I knew very little going in and loved it.  So excited for what is to come!

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213: Brown Eyed Girl

There has been a bit of a buzz in the Outlander world about eye color recently. In particular, many are questioning the eye color of Brianna.  How can two blue eyed parents (as are Jamie and Claire on the Starz production of Outlander) have a child with brown eyes?

People have two copies of most of their genes.  One copy is inherited from their mother and one copy from their father.  These genes come in different versions, or flavors, called alleles.

In the book series, Claire has whiskey colored (brown) eyes, Jamie’s are blue, as are Brianna’s. Recalling our high school biology days, we know that blue eyes are a recessive trait.  To have blue eyes, a person must inherit two copies of the recessive gene.  Claire must have carried Bb (a dominant and a recessive) and Jamie carried bb (both recessive), and Brianna inherited a recessive (blue eyed) allele from each parent, giving her bb.

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The possible eye color of Book Jamie and Book Claire’s children

On screen, both Claire and Jamie have blue eyes and their daughter has brown.

Doesn’t this go against what we all learned about eye color inheritance in high school biology class?

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The possible eye color of TV Jamie and TV Claire’s children

As it turns out, eye color is not nearly that simple.

There are a number of genes influencing eye color, but two in particular are known to play a significant role in the the development of blue or brown eyes.  These are the OCA2 and HERC2 genes located on chromosome 15.

The OCA2 gene determines how much pigment is made, not only in the eyes but in the skin and hair as well. Lots of pigment results in brown eyes. Blue eyes are the result of little to no pigment in the eyes.

Lying next to the OCA2 gene on chromosome 15, the HERC2 gene functions much like a switch, controlling how much expression the OCA2 gene will have and thus how much pigment will be present in the eye. It is thought that originally, all humans had brown eyes, and a single mutation in the HERC2 gene created this “switch,” leading to the development blue eyes. It is now believed that all blue eyed people descended from one common ancestor who developed this mutation!

The OCA2 gene comes in two varieties:

O (brown – dominant) and o (blue – recessive)

Inheriting OO or Oo results in a message to make lots of pigment and thus, brown eyes

Inheriting oo results in message to make little to no pigment and thus, blue eyes

The HERC2 gene comes in two varieties:

H (switch is on) and h (switch is off)

HH and Hh code for allowing for expression of the OCA2 gene

hh results in a limitation of the expression of the OCA2 gene

If a person inherits two “h” copies of the HERC2 gene, it doesn’t matter what eye color the OCA2 gene carries. The switch is turned off and expression of the OCA2 gene is limited.  Little to no pigment is produced and blue eyes result.

OCA2 HERC2 phenotypes
The possible combinations of the OCA2 and HERC2 genes and their resultant eye color

Thus, a parent with blue eyes can carry the trait for brown eyes if they carry the OO or Oo version of the OCA2 gene, but with the mutated gene (hh) “switching off” the OCA2 expression.  Even though their OCA2 gene would signal the production of a lot of pigment, and thus brown eyes, the switch is off and little to no pigment is made.  The eyes are blue.

Here are two examples of how two blue-eyed parents can produce brown-eyed offspring:

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blue eyed parents 2

In reality, eye color determination is even more complicated than this, as the OCA2 and HERC2 genes are often linked and travel together during the process of assortment and inheritance.  In addition, the effects of numerous other genes combine with those of OCA2 and HERC2 to create a continuum of eye color (and we do know from the Outlander books that the inheritance of green eyes is an important matter!)

Brown eye color in the offspring of two blue eyed parents is not a common phenomenon, but this is the Outlander world, after all.

Stranger things have happened…

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Read More!

NIH Genetics Home Reference

LiveScience.com – One Common Ancestor Behind Blue Eyes

Stanford at The Tech – Understanding Genetics

Questions? Comments? Suggestions for future Outlander medicine topics? I’d love to hear from you! Leave a comment here or connect on Twitter or Facebook!